Today Apple has released Mac OS X 10.10.4 found here. Currently there are no known issues under this version in regards to Hackintosh systems.
After the update you must re-patch AppleHDA. The download link for the Audio patch can be found on the DMG that you used for Post Install. X99 users should install the Debug AppleHDA on the X99 DMG. X79 users who need the patched kext for Power Management must also reinstall the patched driver on the X79 DMG. Also at this time X79 users should install the updated SSDT on the X79 DMG which includes fixes that address issues under 10.11. Please email me a IOReg after installing and rebooting with the new SSDT. I have only applied the fixes to Asus and Gigabyte boards as I need IOReg’s from other manufactures to include these fixes.
Users who use the Nvidia Retail Drivers must boot with nv_disable=1 after applying the update and then update the Nvidia Retail Drivers using the Nvidia Control Panel.
I would also ask for users to read are last post found here about working on support for the new AMD generation of Graphic Cards.
Please report any issues that you may have and we will see what we can do to address them.